Tuesday, May 7, 2019

Multiple Effects Of Growth Hormone In The Human Body



In the study Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth?, published in 2016 in the journal of Clinical Medical: Endocrinol Diabetes, authors Jesús Devesa, Cristina Almengló, and Pablo Devesa, they point out that "a number of actions of Growth Hormone exerted on multiple tissues and organs [go] far beyond the classic effects of the hormone on the intermediate metabolism and growth. The high diversity of actions of Growth Hormone can be explained only by the fact that the hormone plays many different roles by activating a high number of proteins involved in cell signaling and displaying different mechanisms of action.

The possibility exists that, rather than a hormone, GH is a prohormone that depending on the tissue may be proteolytically cleaved giving origin to different and shorter GH derivatives with tissue-specific properties. In addition, GH may activate the proliferation of tissue-specific stem cells that then would act in tissue repair after an injury.

Moreover, recently, it has been reported that GH is able to induce the rescue of pancreatic β-cell and function in streptozotocin-treated mice and, therefore, may be of interest in the treatment of type 1 diabetes
."

In their paper, Devesa, Almengló and Devesa explain further, "GH may facilitate the proliferation, differentiation, survival, and migration of new neurons in response to brain injury. However, to date, only few studies in human beings explore such a possibility. While these studies indicate a positive effect for GH treatment together with specific neurorehabilitation, both in children with cerebral palsy and in Traumatic Brain Injury patients, or in a patient suffering from a neurogenic dysphagia after oncological brain surgery, all patients in these studies had Growth hormone deficiency most likely occurring as a consequence of their brain damage.

However, we recently demonstrated that GH administration, together with specific rehabilitation, after an important brain injury, is able to recover laboratory animals and patients without Growth hormone deficiency. Similar results have been obtained after a stroke. In rats, delayed and chronic treatment of stroke with central GH may accelerate some aspects of functional recovery and improve spatial memory in the long term, and a pilot study in human patients who suffered a stroke showed improvements after administering GH.

In line with these, the expression of both GH and GHR is strongly upregulated after brain injury and specifically associated with stressed neurons and glia. From these and other studies, it is now clear that GH plays a key role in both physiologic and reparative neurogenesis, being its effect specially marked on cognitive functions, most likely throughout the interaction of the hormone with GHRs expressed in the hippocampus and frontal cortex, brain areas especially related to memory and cognition, respectively.

It is already well known that GHD adults have impaired psychological well-being, including energy, motivation, emotion, memory, and cognition. However, all these abnormalities improved during GH replacement therapy, which leads to marked improvements in the quality of life. The same occurs in GHD after being treated with GH. Attention, perception, and cognitive capacity improve in them. Cognitive impairments and mood disturbances are common findings in patients with GH deficiency. GH treatment significantly improves memory and cognitive functions in these patients, as shown by functional MRI studies. Similar results have been obtained recently by us and others, both in adult GHD patients and in patients with normal GH secretion
."

Many KAATSU Master Specialists have found significant beneficial outcomes have been seen on their patients and clients with Traumatic Brain Injuries [see here] and others experiencing depression or dementia [see here].

As Dr. Sato, the inventor of KAATSU, explains, "GH is said to have psychological effects including the stabilization of emotion. This helps to improve depression and dementia [see video above of a 104-year-old who recovered from dementia with KAATSU].

It is known that GH has positive psychological effects including increasing energy and stabilizing emotion. Secretion of a large amount of GH with KAATSU is believed to work directly on symptoms of depression or dementia including improving a lack of motivation and social withdrawal.

In addition, some say that obesity and depression have a relationship; it is thought that lower physical activity leads to obesity, which exacerbates depression.

KAATSU compensates a lack of exercise and helps to release GH in large amounts resulting in improvement of symptoms
."

KAATSU Master Specialists have seen KAATSU users have increased energy levels and increased stability of the autonomic nerve system which is one factor in improving their emotional stability.

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